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Molecular Therapy - Methods and Clinical Development

eISSN: 2329-0501
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methods, technology development, molecular therapy, gene therapy

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Molecular and Biochemical Parasitology

ISSN: 0166-6851

The journal provides a medium for rapid publication of investigations of the molecular biology and biochemistry of parasitic protozoa and helminths and their interactions with both the definitive and intermediate host. The main subject areas covered are:• the structure, biosynthesis, degradation, properties and function of DNA, RNA, proteins, lipids, carbohydrates and small molecular-weight substances • intermediary metabolism and bioenergetics• drug target characterization and the mode of action of antiparasitic drugs • molecular and biochemical aspects of membrane structure and function• host-parasite relationships that focus on the parasite, particularly as related to specific parasite molecules. (Note that studies predominantly focused on the host response (e.g. immunology) are better suited to other journals.) • analysis of genes and genome structure, function and expression • analysis of variation in parasite populations relevant to genetic exchange, pathogenesis, drug and vaccine target characterization, and drug resistance.• parasite protein trafficking, organelle biogenesis, and cellular structure especially with reference to the roles of specific molecules• parasite programmed cell death, development, and cell division at the molecular levelPapers will only be accepted for publication if they fall within these areas, if they contain original and complete work of high scientific quality, and if they are well presented. Papers solely confirming the conserved functions of genes previously studied in other organisms will not be considered.Most downloaded papersBenefits to authorsWe also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services .Please see our Guide for Authors for information on article submission. If you require any further information or help, please visit our support pages: http://support.elsevier.com

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Molecular and Cellular Biochemistry

ISSN: 0300-8177eISSN: 1573-4919

Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell. In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.

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Molecular and Cellular Biology

ISSN: 0270-7306eISSN: 1098-5549

Molecular and Cellular Biology (MCB) is dedicated to disseminating new findings and advancing new research that contributes to our knowledge of the molecular biology of eukaryotic cells. Examining both microbial and higher organisms, the journal showcases significant discoveries in cellular morphology and function, genome organization, regulation of genetic expression, morphogenesis, and somatic cell genetics. The journal also examines viral systems, publishing papers that emphasize their impact on the cell.

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Molecular and Cellular Endocrinology

ISSN: 0303-7207

Molecular and Cellular Endocrinology was established in 1974 to meet the demand for integrated publication on all aspects related to the biochemical effects, synthesis and secretions of extracellular signals (hormones, neurotransmitters, etc.) and to the understanding of cellular regulatory mechanisms involved in hormonal control.The journal is fulfilling this aim by publishing full-length original research papers, rapid papers, invited reviews, At the Cutting Edge essays, and book reviews.The scope encompasses all subjects related to biochemical and molecular aspects of endocrine research and cell regulation. These include: (1) mechanisms of action of extracellular signals (hormones, neurotransmitters, etc.), (2) interaction of these factors with receptors, (3) generation, action and role of intracellular signals such as cyclic nucleotides and calcium, (4) hormone-regulated gene expression, (5) structure and physicochemical properties of hormones, hormone receptors and other hormone-binding components, (6) synthesis, secretion, metabolism and inactivation of hormones, neurotransmitters, etc. (7) hormonal control of differentiation, (8) related control mechanisms in non-mammalian systems, (9) methodological and theoretical aspects related to hormonal control processes, (10) clinical studies as far as they throw new light on basic research in this field, (11) control of intermediary metabolism at the cellular level, (12) ultrastructural aspects related to hormone secretion and action.Please bookmark this URL: http://www.elsevier.com/locate/mceUS National Institutes of Health (NIH) voluntary posting ("Public Access") policyMolecular and Cellular Endocrinology and Elsevier facilitate the author's response to the NIH Public Access Policy. For more details please see the Guide for authors

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Molecular and Cellular Neuroscience

ISSN: 1044-7431eISSN: 1095-9327

Molecular and Cellular Neuroscience publishes original research of exceptional significance from those areas of the neurosciences indicated by the broadest interpretation of the journal's title. In particular, the journal focuses on synaptic maintenance and organization, neuron-glia communication and regenerative neurobiology. As part of the submission process, authors are asked to state why they consider their paper is of such significance.Furthermore, since rapid peer-review and publication of such research is of paramount importance, extended cycles of article revision and re-review will not be entered into; it is anticipated that authors will fully address all referees' comments during the course of a single revision of their original manuscript.US National Institutes of Health (NIH) voluntary posting ("Public Access") policyMolecular & Cellular Neuroscience and Elsevier facilitate the author's response to the NIH Public Access Policy. For more details please see the Guide for authors

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Molecular and Cellular Pediatrics

eISSN: 2194-7791
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The German Society of Pediatrics and Adolescent Medicine (DGKJ) are providing financial support to aid any authors who require assistance with the article-processing charge (1750 EUR/ 1375 GBP/ 2150 USD). If you do not have access to a funding source, please request DGKJ sponsorship during the submission process, by entering the code RA-DGKJ-MACP-1118 on the payment page. The sponsorship will cover the full cost of the article-processing charge.

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Molecular and Cellular Pharmacology

ISSN: 1938-1247
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Molecular and Cellular Probes

ISSN: 0890-8508eISSN: 1096-1194
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MCP - Advancing Biomedical & Biological Sciences wants to capture outcomes from the current revolution in molecular technologies and sciences. The journal has broadened its scope and embraces any high quality research papers, reviews and opinions in areas including, but not limited to, molecular biology, cell biology, biochemistry, immunology, physiology, epidemiology, ecology, virology, microbiology, parasitology, genetics, evolutionary biology, genomics (including metagenomics), bioinformatics, proteomics, metabolomics, glycomics, and lipidomics. Submissions with a technology-driven focus on understanding normal biological or disease processes as well as conceptual advances and paradigm shifts are particularly encouraged. The Editors welcome fundamental or applied research areas; pre-submission enquiries about advanced draft manuscripts are welcomed. Top quality research and manuscripts will be fast-tracked.Benefits to authorsWe also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services.Please see our Guide for Authors for information on article submission. If you require any further information or help, please visit our support pages: http://support.elsevier.com

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Molecules and Cells

eISSN: 0219-1032

Molecules and Cells is owned and published by the Korean Society for Molecular and Cellular Biology. It is published monthly in a printed and an electronic version. Information about the journal is available online at: http://molcells.org. Its editorial policies are the responsibility of the Editor-in-Chief, the Associate Editors, the Advisory Board, and the Editorial Board under the general authority of the Publications Committee and the Council. Molecules and Cells publishes papers based on original research that are judged, after editorial review, to make a substantial contribution to the understanding of any area of molecular and cellular biology. Manuscripts may be submitted for consideration as Research Articles or Communications. The journal also publishes Minireviews, all of which are by invitation only.

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Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

ISSN: 0027-5107

Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis broadly encompasses all aspects of research that address the detection of mutations, the mechanisms by which mutations in genes and chromosomes arise, and the modulation of mutagenesis by mutation avoidance pathways such as DNA repair, cell cycle control and apoptosis. It includes the role of genetic variation in the genesis and manifestation of mutations, ranging from the variable manner in which xenobiotics are metabolized to variations in the capacity of cells to replicate and repair damaged DNA. It also includes the contributions of these mechanisms, when perturbed, to animal disease models and to human disease, with particular emphasis on carcinogenic mechanisms. The Journal will publish articles on the genesis of aneuploidy and isodisomy, including the roles played by recombination, cell cycle checkpoints, spindle microtubules, centrosomes and kinetocore proteins, and agents that might disrupt them. Submission of appropriate epidemiological studies as well as consequences, including methods for high throughput SNP detection, whole genome and exonic sequencing, DNA microarrays, RNAseq approaches and proteomics are welcome. Submission of preliminary epidemiological studies that associate SNPs with a phenotype but provide no mechanistic insight is discouraged. The broader scope of the journal is a reflection of the rapid advances in the field of mutation research and the recognition that understanding of the mutagenic process requires full knowledge of the cellular response to DNA damage including DNA repair, cell cycle checkpoint arrest and apoptosis.Benefits to authorsWe also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services .Please see our Guide for Authors for information on article submission. If you require any further information or help, please visit our support pages: http://support.elsevier.com

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Mycologia

ISSN: 0027-5514eISSN: 1557-2536

MYCOLOGIA publishes papers on all aspects of the fungi, including lichens. Subjects appropriate to the journal are physiology and biochemistry, ecology, pathology, development and morphology, systematics, cell biology and ultrastructure, genetics, molecular biology, evolution, applied aspects, and new techniques. Publication in MYCOLOGIA is for both members and nonmembers of the Mycological Society of America. Papers appropriate for the journal are:(i) regular articles reporting original research(ii) notes or brief articles reporting research or new techniques(iii) invited papers(iv) reviews, and minireviews.

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Mycorrhiza

ISSN: 0940-6360eISSN: 1432-1890

Mycorrhiza is an international journal devoted to research into mycorrhizas - the widest symbioses in nature, involving plants and a range of soil fungi world-wide. The journal covers research into mycorrhizas, including molecular biology of the plants and fungi, fungal systematics, development and structure of mycorrhizas, and effects on plant physiology, productivity, reproduction and disease resistance. Coverage extends to interactions between mycorrhizal fungi and other soil organisms, and effects of mycorrhizas on plant biodiversity and ecosystem structure. Mycorrhiza presents original papers, short notes and review articles, along with commentaries and news items. It offers a platform for new concepts and discussions, and serves as the basis for a forum of mycorrhizologists from around the world. Managing Editors: Vivienne Gianinazzi-Pearson, Dijon, France, and Randy Molina, Gresham, Oregon, USA Mycorrhiza is the official organ of the International Mycorrhiza Society.

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Nature Chemical Biology

ISSN: 1552-4450eISSN: 1552-4469

Nature Chemical Biology is an international monthly journal that provides a high-visibility forum for the publication of top-tier original research and commentary for the chemical biology community. Chemical biology is an emerging field that combines the scientific ideas and approaches of chemistry, biology and allied disciplines to understand and manipulate biological systems with molecular precision. The journal publishes papers from the expanding community of chemical biologists, including contributions from chemists who are applying the principles and tools of chemistry to biological questions and from biologists who are interested in understanding and controlling biological processes at the molecular level.We give priority to studies that report significant conceptual or practical advances in any area where chemistry and biology intersect. The journal is primarily interested in basic research, especially those studies that report new chemical or biological tools or present significant new molecular-level insights into the mechanisms underpinning biological processes. Additionally, because chemical biology approaches have broad utility for manipulating or engineering biological systems, the journal also considers manuscripts describing applied molecular studies at the chemistry-biology interface. Independent of the scientific area, we seek manuscripts that blend chemistry and biology in new ways, particularly those that provide major conceptual or methodological advances that are likely to open up innovative avenues of research in the field. The journal strives for a fair but comprehensive review process that emphasizes rigorous chemical and biological characterization.In addition to publishing original research, Nature Chemical Biology is a forum for the exchange of ideas between scientists in the chemical and life sciences and a community resource for this emerging field. To this end, we publish content including scholarly reviews and perspectives, highlights of research published in our pages and in other journals, correspondence and commentaries that present topics of scientific and community interest.

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Nature Methods

ISSN: 1548-7091eISSN: 1548-7105

Nature Methods is a forum for the publication of novel methods and significant improvements to tried-and-tested basic research techniques in the life sciences. This monthly publication is aimed at a broad, interdisciplinary audience of academic and industry researchers actively involved in laboratory practice. It provides them with new tools to conduct their research and places a strong emphasis on the immediate practical relevance of the work presented.The journal publishes primary research papers as well as overviews of recent technical and methodological developments. We are actively seeking primary methods papers of relevance to the biological and biomedical sciences, including methods grounded in chemistry that have a practical application to the study of biological problems.To enhance the practical relevance of each paper, description of the method must be accompanied by its validation, its application to an important biological question and results illustrating its performance in comparison to available approaches. Articles are selected for publication that present broad interest, thorough assessments of methodological performance and comprehensive technical descriptions that facilitate immediate application.Specific areas of interest include, but are not limited to:* Methods for nucleic acid manipulation, amplification and sequencing* Methods for protein engineering, expression and purification* Methods for proteomics, including mass spectrometry, analysis of binding interactions, microarray-based technologies, display techniques, analysis of post-translational modifications, glycobiology and metabolomics* Methods for systems biology, including proteomics approaches, protein interaction analysis methods and genome wide expression and regulation profiling* Biomolecular structural analysis technologies, including NMR and crystallography* Chemical biology techniques, including chemical labeling, methods for expanding the genetic code and directed evolution* Biophysical methods, including single molecule and lab-on-a-chip technologies* Optical and non-optical imaging technologies, including probe design and labeling methods, microscopy, spectroscopy and in vivo imaging* Techniques for the analysis and manipulation of gene expression, including epigenetics, gene targeting, transduction, RNA interference and microarray-based technologies* Methods for cell culture and manipulation, including stem cells, single cell methods and lab-on-a-chip technologies* Immunological techniques, including production of antibodies, antibody-based assays and immunolabeling* Methods for the study of physiology and disease processes including cancer* Methods involving model organisms and their manipulation and phenotyping* Computational and bioinformatic methods for analysis, modeling or visualization of biological data* Nanotechnology-based methods applied to basic biology.

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Nature Reviews Genetics

ISSN: 1471-0056eISSN: 1471-0064

To an extent, all life scientists are geneticists because genetic technology and the accumulation of genomic information have enriched all of biology. You may or may not call yourself a geneticist, but if you work on or with genes you need to know about the latest developments. Nature Reviews Genetics covers the full scientific breadth of modern genetics, capturing its excitement, diversity and implications.Subjects covered * Genomics: genome sequencing, genome projects, bioinformatics, cancer genomics, metagenomics, pharmacogenomics, resources * Functional genomics: transcriptomics, functional genomics screens, bioinformatics * Evolutionary genetics: evo-devo, genome evolution, comparative genomics, population genetics, phylogenetics * Technology: new techniques, experimental strategies, therapy, applied genetics and genomics, computational biology * Gene expression: gene regulatory elements, transcriptional and post-transcriptional regulation, regulatory RNAs, broad perspectives on gene regulation, gene expression profiling, gene regulatory networks * Multifactorial genetics: complex traits, mapping strategies, technology, genetic variation * Disease: disease gene identification, relationship between genotype and phenotype, molecular pathology of genetic disease, complex disease, disease susceptibility/resistance * Chromosome biology: DNA elements, telomeres, centromeres, mobile elements, chromosome stability, DNA damage, meiosis and mitosis, nuclear organization, artificial chromosomes * Epigenetics: DNA methylation, histone modification, chromatin structure, imprinting, chromatin remodeling, epigenomics * Developmental biology: patterning, differentiation, stem cells, reproductive technology * Systems and networks: systems biology, biological networks, synthetic biology, modelling * Ethical, legal and social implications of genetics and genomics.

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Nature Reviews Molecular Cell Biology

ISSN: 1471-0072eISSN: 1471-0080

Molecular cell biology is a marriage of two distinct, yet complementary, disciplines. In its traditional sense, the term 'molecular biology' refers to study of the macromolecules essential to life — nucleic acids and proteins. The field of cell biology is a natural extension of this, integrating what we know at the molecular level into an understanding of processes and interactions at the cellular level. Only by combining both fields can we paint a broad picture of essential biological processes such as how cells divide, grow, communicate and die.Nature Reviews Molecular Cell Biology takes readers on a journey from the nucleus of a cell to its boundaries and beyond. It features Reviews and Perspectives articles on a broad range of topics, and highlights important primary papers and technological progress. The scope of the journal includes:Subjects covered * Cell signalling (signalling networks, ion channels, gap junctions) * Membrane dynamics (membrane organization, endocytosis, exocytosis, organelle biogenesis) * Cell adhesion (adhesion molecules, extracellular matrix) * Cytoskeletal dynamics (cell motility, molecular motors, actin, microtubules, intermediate filaments) * Developmental cell biology (developmental signalling, differentiation, asymmetric cell division, stem cells) * Cell growth and division (cell cycle, cytokinesis, cancer) * Cell death (apoptosis, necrosis, autophagy, ageing) * Cellular microbiology (host–pathogen interactions) * Plant cell biology * Gene expression (transcription, splicing, RNA stability, translation, RNA interference, circadian rhythms) * Nucleic-acid metabolism (DNA repair, recombination and replication, RNA biogenesis) * Chromosome biology (chromatin, chromosome structure, transposons) * Nuclear transport (import and export of molecules to and from the nucleus) * Bioenergetics (respiration, photosynthesis, organelle biochemistry) * Protein structure and metabolism (structure-function relationships, quality control, post-translational modifications, folding, translocation, degradation) * Technology and techniques (imaging, proteomics, systems biology, bioinformatics).

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Nature Structural and Molecular Biology

ISSN: 1545-9993eISSN: 1545-9985

Nature Structural & Molecular Biology is an integrated forum for structural and molecular studies. The journal places a strong emphasis on functional and mechanistic understanding of how molecular components in a biological process work together. Structural data may provide such insights, but they are not a pre-requisite for publication in the journal.Specific areas of interest include, but are not limited to:* Structure and function of proteins, nucleic acids and other macromolecules* Structure and function of multi-component complexes* DNA replication, repair and recombination* Chromatin structure and remodeling* Transcription* RNA processing* Translation* Regulation of transcription and translation* Functions of noncoding RNAs* Protein folding, processing and degradation* Sorting and trafficking of proteins and RNA* Signal transduction and intracellular signaling* Membrane processes* Cell surface proteins and cell-cell interactions* Molecular basis of disease.

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Neurobiology of Stress

eISSN: 2352-2895
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Neurobiology of Stress is a multidisciplinary journal for the publication of original research and review articles on basic, translational and clinical research into stress and related disorders. It will focus on the impact of stress on the brain from cellular to behavioral functions and stress-related neuropsychiatric disorders (such as depression, trauma and anxiety). The translation of basic research findings into real-world applications will be a key aim of the journal.

Basic, translational and clinical research on the following topics as they relate to stress will be covered:

  • Molecular substrates and cell signaling
  • Genetics and epigenetics
  • Stress circuitry
  • Structural and physiological plasticity
  • Developmental Aspects
  • Laboratory models of stress
  • Neuroinflammation and pathology
  • Memory and Cognition
  • Motivational Processes
  • Fear and Anxiety
  • Stress-related neuropsychiatric disorders (including depression, PTSD, substance abuse)
  • Neuropsychopharmacology
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Neurochemical Journal

ISSN: 1819-7124eISSN: 1819-7132

The journal provides a source for communication on the latest findings in all areas of contemporary neurochemistry and other fields of relevance (including molecular biology, biochemistry, physiology, neuroimmunology, pharmacology) in order to expand understanding of the functions of nervous system. It presents papers on functional neurochemistry, nervous system receptors, neurotransmitters, myelin, chromaffin granules and other components of the nervous system, as well as neurophysiological and clinical aspects, behavioral reactions, etc. Relevant topics include structure and function of the nervous system proteins, neuropeptides, nucleic acids, nucleotides, lipids, and other biologically active components. The journal presents theoretical material suggesting novel principles and approaches to neurochemical problems, presentations of new hypotheses and significant findings, discussions, chronicles of congresses, meetings, and conferences with short presentations of the most sensational and timely reports, in

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